Francis Leblanc

PhD student in Bioinformatics

Université de Montréal, Montreal heart institute

About me

I am an inspired PhD student acting as lead bioinformatician on international human omic projects. I reoriented my career after 10 years in the fitness industry to the field of genomics for it’s exponential potential to better our understanding of human biology. I am passionate about enhancing human healthspan through leveraging new omic technologies.

Interests

Omic technologies
Data visualization
Healthspan
Longevity
Endothelial function
Autophagy
Senescence
Reason and critical thinking

Education

PhD in Bioinformatics, 2020

Université de Montréal
MSc in Bioinformatics (transitioned to PhD), 2019-2020

Université de Montréal
BSc in Biochemistry, genomic specialization, honor program, 2016-2019

Université de Montréal

Skills

Tidyverse, Shiny, RMarkdown, Blogdown

Pytorch, Numpy

Statistics

Omic assays

Genotyping, RNAseq, ATACseq, Proteomic, Single-cell

Experience

PhD student in Bioinformatics

Lettre lab

Jun 2019 – Present Montreal

Bulk and single cell RNAseq and ATACseq sample optimization, library preperation and bioinformatic analyses
Proteomic & Genotyping bioinformatic analyses
Reseach and experimental design

Deep learning internship

IRIC, Lemieux lab

Jan 2019 – Apr 2019 Montreal

Development of a neural network for transcriptome reads prediction

Teaching assistant

Université de Montréal

Sep 2018 – Apr 2020 Montreal

Assist students during practical work with Linux, Pymol, R and databases (Blast, UniProt, PDB and GenBank).

Human genomic internship

Lettre lab

May 2018 – Aug 2018 Montreal

Exploring the different inflammatory responses of two endothelial cell models using the RNAseq and ATACseq methods

Personal trainer and business owner

Core entraînement fonctionnel

Aug 2006 – Jun 2020 Montreal

Postural and general health analysis
Exercise programs design
Movement demonstrations and education
Business management & development

Distinctions

Prize for the best academic performance of the baccalaureate in biochemistry and molecular medicine

Université de Montréal Jun 2019

Canada Graduate Scholarships-Master’s Program

CIHR Jun 2019

Recent Publications

Filtering publications.

Major cell-types in multiomic single-nucleus datasets impact statistical modeling of links between regulatory sequences and target genes

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Epigenomic profiling, including ATACseq, is one of the main tools used to define enhancers. Because enhancers are overwhelmingly …

Francis JA Leblanc, Guillaume Lettre

Source Document DOI

Transcriptomic Profiling of Canine Atrial Fibrillation Models After One Week of Sustained Arrhythmia

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Background:
Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with increased morbidity, mortality, and …

Francis J.A. Leblanc, Faezeh Vahdati Hassani, Laura Liesinger, Xiaoyan Qi, Patrice Naud, Ruth Birner-Gruenberger, Guillaume Lettre, Stanley Nattel

Source Document DOI

Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene

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Background
Genome-wide association studies (GWAS) have identified hundreds of loci associated with coronary artery disease (CAD) and …

Lalonde S, Codina-Fauteux VA, de Bellefon SM, Francis Leblanc, Beaudoin M, Simon MM, Dali R, Kwan T, Lo KS, Pastinen T, Lettre G

Source Document

L’apprentissage machine pour la prédiction de peptides immunogènes à partir de RNAseq de tumeur

Plusieurs stratégies sont présentement explorées afin de conditionner le système immunitaire à reconnaître les cellules tumorales. …

Francis Leblanc, J. Zumer, S. Lemieux

Symposium des étudiants du cheminement honor

Les TeloHAEC, un modèle endothélial prometteur pour l’étude de variations génétiques

La réponse inflammatoire transcriptomique et de la chromatine des HCAEC et teloHAEC au TNF-α et IL-1β sont analogues ainsi que leur distribution de la variance inter-échantillons.

Francis Leblanc, S. Lalonde, V. Codina-Fauteux, K. Sin Lo, G. Lettre

PREMIER 52e congrès